Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 6/20 | 0.40 |
| ▸ | FLT3 | P36888 | 7/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21211267 | 0.84 | SCN5A (0.52) | SCN5ASMPD3LMNAKDM4E | |
| SCHEMBL21370421 | 0.82 | SCN5A (0.38) | SCN5ASMPD3LMNASMN1; SMN2NPC1 | |
| SCHEMBL10308911 | 0.77 | SCN5A (0.48) | SCN5ASMPD3FLT3CCNT1PIK3CA | |
| SCHEMBL17830895 | 0.76 | SCN5A (0.47) | SCN5ASMPD3FLT3CCNT1PIK3CA | |
| SCHEMBL26352050 | 0.74 | TGFBR1 (0.46) | — | |
| SCHEMBL15280676 | 0.74 | PIM1 (0.49) | SCN5ASMPD3 | |
| SCHEMBL21941666 | 0.74 | SCN5A (0.49) | SCN5ASMPD3FLT3PIK3CA | |
| SCHEMBL31624120 | 0.73 | MEN1 (0.46) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL17132558 | 0.71 | SCN5A (0.43) | SCN5ASMPD3KDM4E | |
| SCHEMBL13990583 | 0.71 | TGFBR2 (0.50) | SCN5ASMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981944-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC (US) | 2018-05-29 | — | — | US | disclosed |
| US-20160264553-A1 | GDF-8 Inhibitors | MIDCAP FINANCIAL TRUST | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264553-A1 | GDF-8 Inhibitors | CXCL8, MSTN, LGALS8 | SCN5A 2254/4885SMPD3 1963/4885FLT3 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.