Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11146076 | 0.85 | LMNA (0.64) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1422386 | 0.83 | GAA (0.74) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6594783 | 0.82 | LMNA (0.64) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7358861 | 0.81 | LMNA (0.60) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL17114436 | 0.79 | MAPK1 (0.65) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7893624 | 0.79 | LMNA (0.57) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7904262 | 0.78 | ALDH1A1 (0.70) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL1807729 | 0.77 | ALDH1A1 (0.58) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL12793245 | 0.77 | POLB (0.88) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13995367 | 0.76 | LMNA (0.64) | LMNAGAAALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1801108-B9 | MORPHOLINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATIONS | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-11-20 | — | — | EP | disclosed |
| EP-1801108-B1 | MORPHOLINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATIONS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-7935700-B2 | Morpholine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-05-03 | — | — | US | disclosed |