Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358861 | 0.85 | LMNA (0.60) | ALDH1A1GAALMNAKDM4EUSP2 | |
| SCHEMBL11146076 | 0.81 | LMNA (0.64) | ALDH1A1GAALMNAKDM4EPOLB | |
| SCHEMBL9587814 | 0.79 | ALDH1A1 (0.65) | ALDH1A1GAALMNAKDM4EUSP2 | |
| SCHEMBL1422386 | 0.79 | GAA (0.74) | ALDH1A1GAALMNAPOLBSMN1; SMN2 | |
| SCHEMBL7893624 | 0.78 | LMNA (0.57) | ALDH1A1GAALMNAKDM4EUSP2 | |
| SCHEMBL17114436 | 0.78 | MAPK1 (0.65) | ALDH1A1GAALMNAUSP2SMN1; SMN2 | |
| SCHEMBL6594783 | 0.78 | LMNA (0.64) | ALDH1A1GAALMNAPOLBSMN1; SMN2 | |
| SCHEMBL1807728 | 0.77 | LMNA (0.60) | ALDH1A1GAALMNAHSD17B10POLB | |
| SCHEMBL7904262 | 0.77 | ALDH1A1 (0.70) | ALDH1A1GAALMNAKDM4EUSP2 | |
| SCHEMBL15840665 | 0.77 | SMN1; SMN2 (0.69) | ALDH1A1GAALMNAUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1801108-B9 | MORPHOLINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATIONS | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-11-20 | — | — | EP | disclosed |
| EP-1801108-B1 | MORPHOLINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATIONS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-7935700-B2 | Morpholine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-05-03 | — | — | US | disclosed |