Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 8/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16475032 | 0.88 | ABL1 (0.41) | MAT2AROCK2 | |
| SCHEMBL18077794 | 0.85 | BRD4 (0.38) | MAT2AMAPT | |
| SCHEMBL18811825 | 0.81 | ROCK2 (0.34) | ROCK2MAPT | |
| SCHEMBL18077782 | 0.81 | CHUK (0.35) | ROCK2MAPT | |
| SCHEMBL18812267 | 0.81 | GRK2 (0.36) | ROCK2MAPT | |
| SCHEMBL17803975 | 0.79 | GRK2 (0.38) | ROCK2MAPT | |
| SCHEMBL18812254 | 0.78 | AURKA (0.39) | — | |
| SCHEMBL18077733 | 0.78 | ROCK2 (0.37) | ROCK2 | |
| SCHEMBL18077691 | 0.77 | ROCK2 (0.34) | ROCK2MAPT | |
| SCHEMBL18077774 | 0.76 | MAPT (0.37) | ROCK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160263090-A1 | ANTI-FIBROTIC PYRIDINONES | GENENTECH, INC. | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263090-A1 | ANTI-FIBROTIC PYRIDINONES | MMP1, COL1A1, COL2A1 | MAT2A 1752/4885ROCK2 1113/4885MAPT 4377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.