Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 15/20 | 0.38 |
| ▸ | ARG2 | P78540 | 15/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079736 | 0.92 | ARG1 (0.46) | ARG1ARG2 | |
| SCHEMBL18079494 | 0.79 | ARG1 (0.40) | ARG1ARG2KDM4EMAPT | |
| SCHEMBL10008908 | 0.78 | ARG1 (0.55) | ARG1ARG2 | |
| SCHEMBL10008910 | 0.73 | ARG1 (0.47) | ARG1ARG2 | |
| SCHEMBL18079487 | 0.72 | ARG2 (0.43) | ARG1ARG2 | |
| SCHEMBL10006086 | 0.72 | ARG2 (0.48) | ARG1ARG2 | |
| SCHEMBL19055955 | 0.71 | ARG1 (0.47) | ARG1ARG2LMNAMAPTRAB9A | |
| SCHEMBL18079474 | 0.71 | ARG2 (0.48) | ARG1ARG2 | |
| SCHEMBL894933 | 0.70 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL18079447 | 0.70 | ARG1 (0.44) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447122-B2 | Arginase inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2016-09-20 | — | — | US | disclosed |