Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.32 |
| ▸ | NMT2 | O60551 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | NMT1 | P30419 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18087662 | 0.87 | GPR35 (0.70) | GPR35LMNATDP1MAOBMEN1 | |
| SCHEMBL8990560 | 0.87 | LMNA (0.43) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL17805844 | 0.81 | GPR35 (0.39) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL9246335 | 0.77 | GPR35 (0.84) | GPR35LMNATDP1MAOBMEN1 | |
| SCHEMBL20344350 | 0.76 | GPR35 (0.68) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11209178 | 0.74 | MAOB (0.56) | GPR35LMNATDP1MAOBMEN1 | |
| SCHEMBL7767608 | 0.73 | GPR35 (0.60) | GPR35LMNATDP1MAOBMEN1 | |
| SCHEMBL21667484 | 0.73 | GPR35 (0.60) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL26846821 | 0.72 | GPR35 (0.49) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL10307303 | 0.72 | TDP1 (0.59) | GPR35LMNATDP1MAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160271277-A1 | Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders | THE GENERAL HOSPITAL CORPORATION | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271277-A1 | Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders | APP, SNCA, MAPT | GPR35 1605/4885LMNA 3481/4885TDP1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.