Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29036632 | 0.92 | CYP3A4 (0.49) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL9910897 | 0.88 | CYP3A4 (0.58) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL7826900 | 0.86 | ALDH1A1 (0.59) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL8528182 | 0.83 | VCAM1 (0.46) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL22289051 | 0.83 | VCAM1 (0.50) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL24253063 | 0.83 | ERN1 (0.50) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL8053279 | 0.82 | TSHR (0.58) | ALDH1A1CYP3A4MAPTHSD17B10TSHR | |
| SCHEMBL1771230 | 0.82 | TSHR (0.43) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL6358033 | 0.79 | ERN1 (0.47) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E | |
| SCHEMBL531943 | 0.79 | ALDH5A1 (0.50) | ALDH1A1CYP3A4MAPTHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157710-A1 | 4-SUBSTITUTED ISOXAZOLE/ISOXAZOLINE (HETERO) ARYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF | PI INDUSTRIES LTD. (IN) | 2020-08-06 | — | — | WO | disclosed |
| WO-2017067837-A1 | MICROBIOCIDAL PHENYLAMIDINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-04-27 | — | — | WO | disclosed |
| US-8445505-B2 | Pyrimidine derivatives as kinase inhibitors | IRM LLC (BM) | 2013-05-21 | — | — | US | disclosed |
| EP-2331526-A2 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-06-15 | — | — | EP | disclosed |
| US-20110112096-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ITM LLC (BM) | 2011-05-12 | — | — | US | disclosed |
| WO-2009158431-A2 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112096-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | IGF1R, TYMP, PDXK | ALDH1A1 618/4885CYP3A4 3631/4885MAPT 4028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.