SCHEMBL18088474

SCHEMBL18088474

O=S(=O)(O)c1ccc(OCC2CCC(COc3ccc(S(=O)(=O)O)cc3)CC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PARP15 Q460N3 4/20 0.56
PARP10 Q53GL7 4/20 0.56
PARP2 Q9UGN5 2/20 0.56
SIGMAR1 Q99720 2/20 0.49
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
PKM P14618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3546668 0.98 PARP15 (0.54) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL19874554 0.98 PARP15 (0.54) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL19891720 0.82 CA1 (0.58) PARP15PARP10PARP2ALDH1A1
SCHEMBL3548626 0.82 PARP15 (0.51) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL18088475 0.82 PARP15 (0.51) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL13589518 0.82 PTGS2 (0.53) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL3546671 0.82 PARP15 (0.51) PARP15PARP10PARP2SIGMAR1ALDH1A1
SCHEMBL29024848 0.80 PARP15 (0.64) PARP15PARP10PARP2SIGMAR1
SCHEMBL15067637 0.79 PKM (0.57) PARP15PARP10PARP2ALDH1A1LMNA
SCHEMBL26796017 0.79 PKM (0.39) PARP15PARP10PARP2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107406379-B Non-explosive bis-sulfonyl azides 戴纳米特诺贝尔爆炸材料和系统工程有限公司 2020-10-16 CN disclosed
US-10385016-B2 Non explosive bis-sulfonyl azides DYNAMIT NOBEL GMBH EXPLOSIVSTOFF-UND SYSTEMTECHNIK (DE) 2019-08-20 US disclosed
US-20180050988-A1 NON EXPLOSIVE BIS-SULFONYL AZIDES DYNAMIT NOBEL GMBH EXPLOSIVSTOFF- UND SYSTEMTECHNIK (DE) 2018-02-22 US disclosed
US-20180050988-A1 NON EXPLOSIVE BIS-SULFONYL AZIDES DYNAMIT NOBEL GMBH EXPLOSIVSTOFF- UND SYSTEMTECHNIK (DE) 2018-02-22 US disclosed
WO-2016146597-A1 NON EXPLOSIVE BIS-SULFONYL AZIDES DYNAMIT NOBEL GMBH EXPLOSIVSTOFF- UND SYSTEMTECHNIK (DE) 2016-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10385016-B2 Non explosive bis-sulfonyl azides ARSA, MSRB3, NES PARP15 509/4885PARP10 647/4885PARP2 349/4885
US-20180050988-A1 NON EXPLOSIVE BIS-SULFONYL AZIDES ARSA, MSRB3, NES PARP15 508/4885PARP10 653/4885PARP2 328/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.