Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 5/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18088475 | 1.00 | PARP15 (0.51) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL20325660 | 0.93 | PARP15 (0.54) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL20325460 | 0.92 | PARP10 (0.55) | PARP15PARP10PARP2ALDH1A1LMNA | |
| SCHEMBL21035567 | 0.89 | PARP15 (0.43) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL29660023 | 0.89 | RORC (0.51) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL18088474 | 0.82 | PARP15 (0.56) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL3546671 | 0.82 | PARP15 (0.51) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL13589518 | 0.82 | PTGS2 (0.53) | PARP15PARP10PARP2PKMALDH1A1 | |
| SCHEMBL19891720 | 0.82 | CA1 (0.58) | PARP15PARP10PARP2ALDH1A1 | |
| SCHEMBL19874554 | 0.81 | PARP15 (0.54) | PARP15PARP10PARP2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659293-B2 | α-Amino-N-hydroxy-acetamide derivatives | NOVARTIS AG (CH) | 2010-02-09 | — | — | US | disclosed |
| US-20080176916-A1 | A-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2008-07-24 | — | — | US | disclosed |
| US-7291634-B2 | α-amino-N-hydroxy-acetamide derivatives | NOVARTIS AG (CH) | 2007-11-06 | — | — | US | disclosed |
| US-20060270719-A1 | 2-[(Cyclopropylmethoxy-benzenesulfonyl)-(4-[1,2,3]triazol-2-yl-benzyl)-amino]-N-hydroxy-acetamide; selective inhibitors of matrix-degrading metalloproteinases, especially MT1-MMP, MMP-2 and MMP-9; Osteoporosis; Antitumor, antiproliferative agents | NOVARTIS AG (CH) | 2006-11-30 | — | — | US | disclosed |
| US-7112611-B2 | 1g(α)-amino-N-hydroxy-acetamide derivatives | NOVARTIS AG (CH) | 2006-09-26 | — | — | US | disclosed |
| US-20040082630-A1 | 1g(a)-Amino-n-hydroxy-acetamide derivatives | NOVARTIS AG (CH) | 2004-04-29 | — | — | US | disclosed |
| EP-1360175-A1 | 1G(A)-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES | Novartis AG (CH) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002064552-A1 | 1g(a)-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270719-A1 | 2-[(Cyclopropylmethoxy-benzenesulfonyl)-(4-[1,2,3]triazol-2-yl-benzyl)-amino]-N-hydroxy-acetamide; selective inhibitors of matrix-degrading metalloproteinases, especially MT1-MMP, MMP-2 and MMP-9; Osteoporosis; Antitumor, antiproliferative agents | MMP9, MMP14, MMP13 | PARP15 493/4885PARP10 810/4885PARP2 389/4885 |
| US-20080176916-A1 | A-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES | MMP1, MMP9, MMP14 | PARP15 516/4885PARP10 857/4885PARP2 480/4885 |
| US-20040082630-A1 | 1g(a)-Amino-n-hydroxy-acetamide derivatives | MMP1, MMP9, MMP13 | PARP15 377/4885PARP10 716/4885PARP2 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.