Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18793811 | 0.82 | OPRM1 (0.66) | ADAMTS5OPRM1ALDH1A1GRM5BLM | |
| SCHEMBL29338182 | 0.81 | OPRM1 (0.52) | ADAMTS5OPRM1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL27099821 | 0.81 | ADAMTS5 (0.51) | ADAMTS5OPRM1ALDH1A1RAB9AGRM5 | |
| SCHEMBL27099786 | 0.81 | ADAMTS5 (0.51) | ADAMTS5OPRM1ALDH1A1GRM5BLM | |
| SCHEMBL13997703 | 0.78 | ADAMTS5 (0.49) | ADAMTS5OPRM1ALDH1A1GRM5BLM | |
| SCHEMBL5559794 | 0.78 | OPRM1 (0.47) | ADAMTS5OPRM1ALDH1A1CA12CA1 | |
| SCHEMBL27099820 | 0.77 | ADAMTS5 (0.48) | ADAMTS5OPRM1ALDH1A1NPC1RAB9A | |
| SCHEMBL18088638 | 0.77 | USP2 (0.57) | ADAMTS5OPRM1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL18088639 | 0.75 | OPRM1 (0.49) | ADAMTS5OPRM1ALDH1A1CA12CA1 | |
| SCHEMBL27099823 | 0.75 | ADAMTS5 (0.51) | ADAMTS5OPRM1ALDH1A1RAB9ASCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016148145-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUND | 大正製薬株式会社 | 2016-09-22 | — | — | WO | disclosed |