Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 6/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18091994 | 0.96 | CHRM4 (0.34) | GABRA5CHRM4GABRA1 | |
| SCHEMBL18092013 | 0.95 | CHRM4 (0.31) | CHRM4 | |
| SCHEMBL18092059 | 0.93 | CNR2 (0.33) | — | |
| SCHEMBL18091965 | 0.87 | ALDH1A1 (0.41) | GABRA5GABRA1 | |
| SCHEMBL285821 | 0.85 | GABRA5 (0.49) | GABRA5CHRM4GABRA1 | |
| SCHEMBL18092055 | 0.85 | GABRA5 (0.31) | GABRA5 | |
| SCHEMBL18091995 | 0.85 | GABRA5 (0.31) | GABRA5 | |
| SCHEMBL18092047 | 0.84 | LIPE (0.35) | — | |
| SCHEMBL18092007 | 0.84 | TP53 (0.31) | — | |
| SCHEMBL18091976 | 0.84 | ACACB (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |