Sugi Predict

Sugi Predict / Compounds / SCHEMBL1809210

SCHEMBL1809210

SCHEMBL1809210

CC(N)Cc1ccc(-c2ccc(Cl)c(C(F)(F)F)c2)o1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.54
▸ LMNA P02545 2/20 0.47
▸ USP2 O75604 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ NOTUM Q6P988 12/20 0.44
▸ CYP1A2 P05177 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ PDE3B Q13370 2/20 0.38
▸ PDE3A Q14432 2/20 0.38
▸ PNMT P11086 1/20 0.38
▸ IDO1 P14902 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1810429 0.83 PNMT (0.51) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL1812746 0.83 KDM4E (0.45) KDM4ELMNAUSP2ALDH1A1GAA
Hydrochloric Acid SCHEMBL1810953 0.82 PNMT (0.50) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL18539931 0.79 KDM4E (0.60) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL18551788 0.76 KDM4E (0.55) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL11699587 0.74 PNMT (0.64) PNMTIDO1
SCHEMBL27880674 0.72 KDM4E (0.44) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL30861661 0.70 KDM4E (0.52) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL1806721 0.70 KDM4E (0.52) KDM4ELMNAUSP2ALDH1A1GAA
SCHEMBL2698021 0.69 NOTUM (0.61) NOTUMCYP1A2PDE3BPDE3AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3885340-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2024-11-27 — — EP disclosed
EP-3885340-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2021-09-29 — — EP disclosed
US-11046713-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2021-06-29 — — US disclosed
EP-3369732-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2021-05-26 — — EP disclosed
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2020-09-24 — — US disclosed
US-10711013-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2020-07-14 — — US disclosed
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2019-04-04 — — US disclosed
US-10118933-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2018-11-06 — — US disclosed
EP-3369732-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2018-09-05 — — EP disclosed
US-20170260206-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2017-09-14 — — US disclosed
US-9657003-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2017-05-23 — — US disclosed
EP-3056485-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS Orion Corporation (FI) 2016-08-17 — — EP disclosed
US-20150203479-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION 2015-07-23 — — US disclosed
US-8975254-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2015-03-10 — — US disclosed
EP-2493858-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2014-07-02 — — EP disclosed
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-09-06 — — US disclosed
EP-2493858-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS Orion Corporation (FI) 2012-09-05 — — EP disclosed
CN-102596910-A Androgen receptor modulating compounds ORION CORP 2012-07-18 — — CN disclosed
WO-2011051540-A9 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-06-21 — — WO disclosed
WO-2011051540-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2011-05-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170260206-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-10118933-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-10711013-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-20200299307-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-20190100536-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-11046713-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-20150203479-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG KDM4E 2389/4885LMNA 4479/4885USP2 3150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.