Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11558371 | 0.92 | GAA (0.44) | GAAMAPTTHRBATML3MBTL1 | |
| SCHEMBL17028515 | 0.89 | MAPT (0.45) | GAAMAPTALDH1A1HTTCYP3A4 | |
| SCHEMBL23692789 | 0.89 | ALDH1A1 (0.46) | GAAMAPTALDH1A1TSHRKMT2A | |
| SCHEMBL7026410 | 0.89 | ALDH1A1 (0.46) | GAAMAPTALDH1A1TSHRKMT2A | |
| SCHEMBL17032291 | 0.89 | ALDH1A1 (0.46) | GAAMAPTALDH1A1TSHRKMT2A | |
| SCHEMBL18039756 | 0.89 | GAA (0.54) | GAAMAPTTHRBATML3MBTL1 | |
| SCHEMBL31170124 | 0.85 | SMN1; SMN2 (0.55) | MAPTL3MBTL1ALDH1A1HTTCYP3A4 | |
| SCHEMBL31170609 | 0.85 | SMN1; SMN2 (0.55) | MAPTL3MBTL1ALDH1A1HTTCYP3A4 | |
| SCHEMBL20822071 | 0.82 | MAPT (0.41) | GAAMAPTALDH1A1TSHRHTT | |
| SCHEMBL12883863 | 0.79 | GAA (0.50) | GAAMAPTTHRBATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2022-05-17 | — | — | US | disclosed |
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2022-05-17 | — | — | US | disclosed |
| CN-107428776-B | Production of 4,5,6, 7-tetrahydroisoxazolo [5,4-c ] pyridin-3-ol | H.隆德贝克有限公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-107428776-B | Production of 4,5,6, 7-tetrahydroisoxazolo [5,4-c ] pyridin-3-ol | H.隆德贝克有限公司 | 2020-10-23 | — | — | CN | disclosed |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2020-07-16 | — | — | US | disclosed |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2020-04-21 | — | — | US | disclosed |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2020-04-21 | — | — | US | disclosed |
| EP-3274331-B1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H LUNDBECK AS (DK) | 2020-02-26 | — | — | EP | disclosed |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2018-03-08 | — | — | US | disclosed |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | H. LUNDBECK A/S (DK) | 2018-03-08 | — | — | US | disclosed |
| EP-3274331-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. Lundbeck A/S (DK) | 2018-01-31 | — | — | EP | disclosed |
| EP-3274331-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. Lundbeck A/S (DK) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016150953-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2016-09-29 | — | — | WO | disclosed |
| WO-2016150953-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOZAXOLO[5,4-C]PYRIDIN-3-OL | H. LUNDBECK A/S (DK) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332478-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRD, GABRA5 | GAA 4307/4885MAPT 1151/4885THRB 718/4885 |
| US-10626123-B2 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | GAA 4320/4885MAPT 1171/4885THRB 714/4885 |
| US-20200223865-A1 | MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL | GABRP, GABRD, GABRA5 | GAA 4307/4885MAPT 1151/4885THRB 718/4885 |
| US-20180065984-A1 | Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol | GABRP, GABRA5, GABRD | GAA 4320/4885MAPT 1171/4885THRB 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.