SCHEMBL1809277

SCHEMBL1809277

COC(=O)c1cc(Cc2ccc(N)c(C(=O)OC)c2)ccc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 1.00
GAA P10253 8/20 1.00
KDM4E B2RXH2 6/20 1.00
HSD17B10 Q99714 3/20 1.00
MAPT P10636 3/20 1.00
HPGD P15428 2/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
CDC25B P30305 1/20 0.62
CASP6 P55212 1/20 0.62
RCE1 Q9Y256 1/20 0.62
CFTR P13569 3/20 0.55
GLA P06280 2/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
ATM Q13315 1/20 0.50
ABL1 P00519 1/20 0.49
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30041521 1.00 ALDH1A1 (1.00) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL4604088 0.92 ALDH1A1 (0.85) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL12846981 0.91 ALDH1A1 (0.82) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL221403 0.89 ALDH1A1 (0.81) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL14081421 0.88 ALDH1A1 (0.78) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL26466965 0.86 ALDH1A1 (0.76) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL27851724 0.86 ALDH1A1 (0.75) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL10581522 0.86 ALDH1A1 (0.75) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL25230816 0.85 ALDH1A1 (0.73) ALDH1A1GAAKDM4EHSD17B10MAPT
SCHEMBL7649762 0.85 ALDH1A1 (0.73) ALDH1A1GAAKDM4EHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2220034-B1 AROMATIC ALDIMINES AND POLYURETHANE COMPOSITIONS WHICH CONTAIN ALDIMINE SIKA TECHNOLOGY AG (CH) 2015-12-23 EP claimed
US-8668986-B2 Aromatic aldimines and polyurethane compositions which contain aldimine SIKA TECHNOLOGY AG (CH) 2014-03-11 US claimed
US-20100255314-A1 AROMATIC ALDIMINES AND POLYURETHANE COMPOSITIONS WHICH CONTAIN ALDIMINE SIKA TECHNOLOGY AG (CH) 2010-10-07 US claimed
EP-0579989-B1 Polyurethaneurea elastomer IHARA CHEMICAL IND CO (JP) 1997-09-03 EP claimed
US-5410009-A Impact resilience; flexural properties IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-25 US claimed
US-5300492-A Suppressing levels of sex hormones in male or female mammals TAP PHARMACEUTICALS (US) 1994-04-05 US claimed
EP-0579989-A1 Polyurethaneurea elastomer IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1994-01-26 EP claimed
US-5039775-A Process for producing polyurea resin IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1991-08-13 US claimed
US-4327204-A Process for producing polyurethane elastomer by mixing a hardener composition with an isocyanate composition IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1982-04-27 US claimed
US-4107151-A FROM POLYISOCYANATE, CHAIN POLYOL, AROMATIC DIAMINE, POLYOL OR AMINO ALCOHOL WITH URETHANE BOND IHARA CHEMICAL COMPANY CO., LTD. (JP) 1978-08-15 US claimed
US-4096129-A Glutarate-containing polyesterpolyols, methods of preparation and polyurethane compositions derived therefrom FABRIDYNE, INC. (US) 1978-06-20 US claimed
US-12617890-B2 Polyurethane multi-part kit system LANXESS SOLUTIONS AUSTRALIA PTY. LTD. (AU) 2026-05-05 US disclosed
US-12503575-B2 Fine hollow particles comprising melamine-based resin KAGOSHIMA UNIVERSITY (JP) 2025-12-23 US disclosed
US-20240360335-A1 EPOXY RESIN COMPOSITIONS, COMPOSITE MATERIALS, AND METHODS OF COATING SUBSTRATES Westlake Epoxy Inc. 2024-10-31 US disclosed
US-20240301171-A1 NOVEL FINE HOLLOW PARTICLES COMPRISING MELAMINE-BASED RESIN KAGOSHIMA UNIVERSITY (JP) 2024-09-12 US disclosed
EP-0019232-A1 A process for the preparation of polyurethane-urea elastomers BAYER AG (DE) 1980-11-26 EP disclosed
US-4107151-A FROM POLYISOCYANATE, CHAIN POLYOL, AROMATIC DIAMINE, POLYOL OR AMINO ALCOHOL WITH URETHANE BOND IHARA CHEMICAL COMPANY CO., LTD. (JP) 1978-08-15 US disclosed
US-4096129-A Glutarate-containing polyesterpolyols, methods of preparation and polyurethane compositions derived therefrom FABRIDYNE, INC. (US) 1978-06-20 US disclosed
US-4001180-A METHYLENEBIS(METHYL ANTHRANILATE) AND AN ISOCYANATE-TERMINATED PREPOLYMER DOYLE EARL N 1977-01-04 US disclosed
US-3989568-A CONTROLLING RATE OF CURING ACUSHNET COMPANY (US) 1976-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12617890-B2 Polyurethane multi-part kit system FANCI, FANCD2, RAD50 ALDH1A1 753/4885GAA 2475/4885KDM4E 3238/4885
US-20100255314-A1 AROMATIC ALDIMINES AND POLYURETHANE COMPOSITIONS WHICH CONTAIN ALDIMINE ODC1, DDC, SRM ALDH1A1 43/4885GAA 1814/4885KDM4E 206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.