Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935138 | 0.85 | TDP1 (0.44) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL7486384 | 0.81 | TDP1 (0.47) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL10850237 | 0.81 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL9518730 | 0.81 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL5424436 | 0.78 | TDP1 (0.42) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL11099599 | 0.77 | TSHR (0.49) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8331526 | 0.77 | ALDH1A1 (0.48) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL2203256 | 0.77 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8329625 | 0.76 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL3817895 | 0.76 | TSHR (0.42) | L3MBTL1ALDH1A1LMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351591-B2 | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-07-16 | — | — | US | disclosed |
| US-20180105553-A1 | POLYPEPTIDES, PEPTIDES, AND PROTEINS FUNCTIONALIZED BY ALKYLATION OF THIOETHER GROUPS VIA RING-OPENING REACTIONS | NATIONAL SCIENCE FOUNDATION | 2018-04-19 | — | — | US | disclosed |
| WO-2016154120-A1 | POLYPEPTIDES, PEPTIDES, AND PROTEINS FUNCTIONALIZED BY ALKYLATION OF THIOETHER GROUPS VIA RING-OPENING REACTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105553-A1 | POLYPEPTIDES, PEPTIDES, AND PROTEINS FUNCTIONALIZED BY ALKYLATION OF THIOETHER GROUPS VIA RING-OPENING REACTIONS | PTMS, TMT1A, PTMA | L3MBTL1 3228/4885ALDH1A1 2728/4885LMNA 4521/4885 |
| US-10351591-B2 | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions | PTMS, TMT1A, PTMA | L3MBTL1 3228/4885ALDH1A1 2728/4885LMNA 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.