SCHEMBL1809663

SCHEMBL1809663

CC(C)(C)OC(=O)N1CCCC1C(=O)O.O=C(O)C1CCCN1C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.56
RAB9A P51151 1/20 0.52
LMNA P02545 2/20 0.50
NPC1 O15118 1/20 0.50
CYP2C19 P33261 1/20 0.50
ALDH1A1 P00352 2/20 0.49
NPSR1 Q6W5P4 1/20 0.48
UCHL1 P09936 2/20 0.46
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
POLB P06746 1/20 0.44
KLK7 P49862 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL67044 0.95 HSD17B10 (0.69) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL27877016 0.95 HSD17B10 (0.69) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL6219872 0.95 HSD17B10 (0.69) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL67045 0.95 HSD17B10 (0.69) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL85536 0.95 HSD17B10 (0.69) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL20492528 0.94 HSD17B10 (0.68) HSD17B10SMN1; SMN2RAB9ALMNANPC1
Ammonia Solution, Strong SCHEMBL28264574 0.94 HSD17B10 (0.68) HSD17B10SMN1; SMN2RAB9ALMNANPC1
Hydrazine SCHEMBL28122430 0.92 HSD17B10 (0.66) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL77858 0.90 HSD17B10 (0.63) HSD17B10SMN1; SMN2RAB9ALMNANPC1
SCHEMBL65491 0.90 HSD17B10 (0.63) HSD17B10SMN1; SMN2RAB9ALMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016178250-A1 PROCESS FOR THE PREPARATION OF DACLATASVIR MYLAN LABORATORIES LIMITED (IN) 2016-11-10 WO disclosed
EP-2499132-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2012-09-19 EP disclosed
WO-2011060000-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-05-19 WO disclosed