Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.48 |
| ▸ | WNT3A | P56704 | 3/20 | 0.48 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1573525 | 0.88 | KDM4E (0.80) | KDM4EGAAPDPK1CYP3A4CCNA2 | |
| Carbamic Acid SCHEMBL1857015 | 0.86 | KDM4E (0.77) | KDM4EGAAPDPK1CYP3A4CCNA2 | |
| Urea SCHEMBL2190330 | 0.84 | KDM4E (0.80) | KDM4EGAAPDPK1CYP3A4CCNA2 | |
| Trifluoroacetic Acid SCHEMBL15546473 | 0.84 | FLT3 (0.54) | KDM4ECCNA2CDK2FLT3CCNA1 | |
| SCHEMBL18878 | 0.82 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4FLT3 | |
| SCHEMBL29481432 | 0.82 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4FLT3 | |
| Biphenyl SCHEMBL27604124 | 0.78 | PDPK1 (0.83) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| SCHEMBL4736094 | 0.76 | KDM4E (0.58) | KDM4ECCNA2CDK2FLT3CCNA1 | |
| Hydrazine SCHEMBL27690059 | 0.74 | FLT3 (0.61) | KDM4EGAAPDPK1CYP3A4CCNA2 | |
| Trifluoroacetic Acid SCHEMBL30233736 | 0.73 | MAPK1 (0.57) | KDM4ECTNNB1WNT3ASTAT3HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3274335-A1 | AMINOINDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016150971-A1 | AMINOINDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-09-29 | — | — | WO | disclosed |