Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.80 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL1857015 | 0.94 | KDM4E (0.77) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| Bicarbonate SCHEMBL1573525 | 0.92 | KDM4E (0.80) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| SCHEMBL29481432 | 0.89 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| SCHEMBL18878 | 0.89 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| Trifluoroacetic Acid SCHEMBL18096685 | 0.84 | KDM4E (0.67) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| SCHEMBL9042255 | 0.80 | KDM4E (0.73) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| SCHEMBL82761 | 0.78 | KDM4E (0.62) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| Hydrochloric Acid SCHEMBL5071439 | 0.77 | KDM4E (0.60) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| Hydrochloric Acid SCHEMBL2175299 | 0.77 | KDM4E (0.60) | KDM4EGAAPDPK1CYP3A4YTHDC1 | |
| Hydrochloric Acid SCHEMBL30404733 | 0.77 | KDM4E (0.60) | KDM4EGAAPDPK1CYP3A4YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102197-B1 | 5-([1,3,4]OXADIAZOL-2-YL)-1H-INDAZOL AND 5-([1,3,4]THIADIAZOL-2-YL)-1H-INDAZOL DERIVATIVES AS SGK INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-2102197-A1 | 5-([1,3,4]OXADIAZOL-2-YL)-1H-INDAZOL AND 5-([1,3,4]THIADIAZOL-2-YL)-1H-INDAZOL DERIVATIVES AS SGK INHIBITORS FOR THE TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| CN-101489551-A | Aminoindazole urea derivatives | MERCK PATENT GMBH (DE) | 2009-07-22 | — | — | CN | disclosed |
| EP-2040701-A2 | AMINOINDAZOLE UREA DERIVATIVES | Merck Patent GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008086854-A1 | 5-([1,3,4] OXADIAZOL-2-YL)-1H-INDAZOL AND 5-([1,3,4] THIADIAZOL-2-YL)-1H-INDAZOL DERIVATIVES AS SGK INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008009335-A3 | AMINOINDAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008009335-A2 | AMINOINDAZOLE UREA DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-01-24 | — | — | WO | disclosed |