Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | GAA | P10253 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | JAK2 | O60674 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | IDO1 | P14902 | 2/20 | 0.64 |
| ▸ | ALPL | P05186 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481432 | 0.91 | PDPK1 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL18878 | 0.91 | PDPK1 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| Bicarbonate SCHEMBL1573525 | 0.86 | KDM4E (0.80) | PDPK1KDM4EGAACYP3A4JAK2 | |
| Carbamic Acid SCHEMBL1857015 | 0.84 | KDM4E (0.77) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL3361070 | 0.82 | JAK2 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL12907246 | 0.82 | JAK2 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL3359889 | 0.82 | JAK2 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL12907241 | 0.82 | JAK2 (1.00) | PDPK1KDM4EGAACYP3A4JAK2 | |
| Urea SCHEMBL2190330 | 0.82 | KDM4E (0.80) | PDPK1KDM4EGAACYP3A4JAK2 | |
| SCHEMBL17178615 | 0.79 | ALDH1A1 (0.92) | PDPK1KDM4EGAACYP3A4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101979382-A | Aminoindazole derivatives and use thereof as kinase inhibitors | AVENTIS PHARMA SA | 2011-02-23 | — | — | CN | claimed |
| CN-1678589-A | Novel aminoindazole derivatives as medicaments and pharmaceutical compositions containing them | AVENTIS PHARMA SA (FR) | 2005-10-05 | — | — | CN | claimed |
| CN-101979382-A | Aminoindazole derivatives and use thereof as kinase inhibitors | AVENTIS PHARMA SA | 2011-02-23 | — | — | CN | disclosed |
| CN-1982316-A | Novel aminoindazole derivatives as medicaments and pharmaceutical compositions including them | AVENTIS PHARMA SA (FR) | 2007-06-20 | — | — | CN | disclosed |
| CN-1678589-A | Novel aminoindazole derivatives as medicaments and pharmaceutical compositions containing them | AVENTIS PHARMA SA (FR) | 2005-10-05 | — | — | CN | disclosed |