Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.80 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL1857015 | 0.94 | KDM4E (0.77) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| Urea SCHEMBL2190330 | 0.92 | KDM4E (0.80) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| SCHEMBL18878 | 0.89 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| SCHEMBL29481432 | 0.89 | PDPK1 (1.00) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| Trifluoroacetic Acid SCHEMBL18096685 | 0.88 | KDM4E (0.67) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| Biphenyl SCHEMBL27604124 | 0.86 | PDPK1 (0.83) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| SCHEMBL9042255 | 0.80 | KDM4E (0.73) | KDM4EGAAPDPK1CYP3A4JAK2 | |
| Hydrazine SCHEMBL27690059 | 0.77 | FLT3 (0.61) | KDM4EGAAPDPK1CYP3A4MAP2K4 | |
| SCHEMBL5353834 | 0.76 | FLT3 (0.65) | KDM4EALDH1A1IDO1CCNA2CDK2 | |
| SCHEMBL42245 | 0.76 | FLT3 (0.65) | KDM4EMAP2K4ALDH1A1IDO1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |