Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18098820 | 0.73 | PDPK1 (0.48) | DYRK1AKCNH2KDM4CGSK3BNFATC1 | |
| SCHEMBL22755778 | 0.72 | TGFBR1 (0.61) | DYRK1AGSK3BCDK2DYRK1B | |
| SCHEMBL18902075 | 0.69 | BRD4 (0.34) | — | |
| SCHEMBL18902127 | 0.69 | JAK2 (0.35) | — | |
| SCHEMBL15388885 | 0.66 | HASPIN (0.61) | DYRK1AKCNH2HASPINGSK3BNFATC1 | |
| SCHEMBL254249 | 0.66 | HTR6 (0.52) | DYRK1A | |
| SCHEMBL4851744 | 0.66 | DYRK1A (0.49) | DYRK1AKCNH2HASPINKDM4CGSK3B | |
| SCHEMBL21917173 | 0.63 | DYRK1A (0.43) | DYRK1AKCNH2HASPINKDM4CGSK3B | |
| SCHEMBL21917358 | 0.63 | DYRK1A (0.62) | DYRK1AKCNH2HASPINGSK3BNFATC1 | |
| SCHEMBL30461707 | 0.63 | DYRK1A (0.62) | DYRK1AKCNH2HASPINGSK3BNFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |