Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18902127 | 0.85 | JAK2 (0.35) | — | |
| SCHEMBL8324439 | 0.78 | MAOB (0.41) | BRD4CYP1A2 | |
| SCHEMBL8324146 | 0.78 | SCN9A (0.36) | BRD4 | |
| SCHEMBL19366321 | 0.75 | ALDH1A1 (0.33) | — | |
| SCHEMBL8256564 | 0.70 | GSK3B (0.39) | — | |
| SCHEMBL17211632 | 0.70 | BRD4 (0.55) | BRD4ELANE | |
| SCHEMBL18098819 | 0.69 | DYRK1A (0.37) | — | |
| SCHEMBL1050312 | 0.69 | BRD4 (0.64) | BRD4 | |
| SCHEMBL13616238 | 0.68 | ALDH1A1 (0.38) | — | |
| SCHEMBL19366587 | 0.68 | SRC (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560972-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2496086-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2017-05-31 | — | — | EP | disclosed |