Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.40 |
| ▸ | GSK3B | P49841 | 6/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22755778 | 0.81 | TGFBR1 (0.61) | PDPK1TGFBR1IKBKETBK1CDK5 | |
| SCHEMBL12501099 | 0.73 | HTR6 (0.54) | PDPK1TGFBR1IKBKETBK1CDK5 | |
| SCHEMBL18098819 | 0.73 | DYRK1A (0.37) | CDK2DYRK1AGSK3BNFATC1KDM4C | |
| SCHEMBL15827817 | 0.71 | PDPK1 (0.51) | PDPK1TGFBR1IKBKETBK1CDK5 | |
| SCHEMBL3354801 | 0.70 | AKT1 (0.37) | TGFBR1PIM1GSK3B | |
| SCHEMBL12501163 | 0.70 | IKBKE (0.56) | PDPK1TGFBR1IKBKETBK1CDK5 | |
| SCHEMBL12501062 | 0.68 | IKBKE (0.64) | PDPK1TGFBR1IKBKETBK1CDK5 | |
| SCHEMBL21317804 | 0.67 | ELANE (0.39) | TGFBR1 | |
| SCHEMBL12501038 | 0.65 | TGFBR1 (1.00) | PDPK1TGFBR1IKBKETBK1CDK2 | |
| SCHEMBL18381816 | 0.64 | PDPK1 (0.44) | PDPK1TGFBR1IKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |