Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 3/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.64 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.53 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.53 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501046 | 0.80 | PDPK1 (0.55) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL12501045 | 0.79 | TGFBR1 (1.00) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL12501038 | 0.76 | TGFBR1 (1.00) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL12501163 | 0.76 | IKBKE (0.56) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL14876913 | 0.75 | IKBKE (0.71) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL12501028 | 0.71 | IKBKE (0.64) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL15827817 | 0.70 | PDPK1 (0.51) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL17179566 | 0.69 | DYRK1A (1.00) | IKBKEPDPK1TGFBR1GSK3BDYRK1A | |
| SCHEMBL30664791 | 0.69 | CCNT1 (0.49) | IKBKEPDPK1TGFBR1TBK1GSK3B | |
| SCHEMBL12501099 | 0.68 | HTR6 (0.54) | IKBKEPDPK1TGFBR1TBK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | claimed |
| EP-2746281-A2 | 7-azaindole derivatives | Merck Patent GmbH (DE) | 2014-06-25 | — | — | EP | claimed |
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| US-9725446-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| US-9725446-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-12 | — | — | US | disclosed |
| US-9266887-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2016-02-23 | — | — | US | disclosed |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-8981101-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| US-8981101-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| EP-2746281-A2 | 7-azaindole derivatives | Merck Patent GmbH (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2670748-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2013-12-11 | — | — | EP | disclosed |
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| WO-2012104007-A2 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | IKBKE 1071/4885PDPK1 12/4885TGFBR1 3500/4885 |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | IKBKE 1071/4885PDPK1 12/4885TGFBR1 3500/4885 |
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | IKBKE 1100/4885PDPK1 12/4885TGFBR1 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.