Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361093 | 0.84 | DAO (0.36) | ACLYDAOTP53MAPTSMN1; SMN2 | |
| SCHEMBL1811874 | 0.84 | DAO (0.38) | ACLYDAOALOX5APFEN1TP53 | |
| SCHEMBL4352199 | 0.81 | BRPF1 (0.44) | DAO | |
| SCHEMBL3902067 | 0.81 | ACLY (0.53) | ACLYSMN1; SMN2 | |
| SCHEMBL1810122 | 0.81 | BRD4 (0.44) | ACLY | |
| SCHEMBL3906452 | 0.80 | ACLY (0.54) | ACLYPTGES2 | |
| SCHEMBL3906066 | 0.80 | ACLY (0.43) | ACLY | |
| SCHEMBL3906639 | 0.80 | ACLY (0.54) | ACLYPTGES2 | |
| SCHEMBL4359474 | 0.80 | MAPT (0.35) | DAOTP53MAPTGAAL3MBTL1 | |
| SCHEMBL3911597 | 0.78 | CCR9 (0.46) | ACLYTP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |