Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812628 | 0.86 | BRPF1 (0.41) | BRPF1GRIN1GRIN2BPARP1DAO | |
| SCHEMBL4355952 | 0.83 | BRPF1 (0.47) | BRPF1GRIN1GRIN2BPARP1BRD4 | |
| SCHEMBL1810258 | 0.81 | ACLY (0.43) | DAO | |
| SCHEMBL1812553 | 0.80 | BRPF1 (0.46) | BRPF1GRIN1GRIN2BPARP1BRD4 | |
| SCHEMBL1819410 | 0.79 | BRD4 (0.41) | PARP1DAOBRD4NR1I2SERPINE1 | |
| SCHEMBL1810608 | 0.79 | BRD4 (0.55) | BRD4SERPINE1 | |
| SCHEMBL1813239 | 0.79 | NR1I2 (0.60) | NR1I2SERPINE1PDE3A | |
| SCHEMBL1811184 | 0.78 | NR1I2 (0.58) | BRD4NR1I2SERPINE1 | |
| SCHEMBL1819641 | 0.78 | PGR (0.57) | BRD4SERPINE1 | |
| SCHEMBL1811576 | 0.78 | HSD17B1 (0.47) | BRD4NR1I2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |