Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15944987 | 0.82 | LPAR2 (0.55) | SMN1; SMN2RAB9ANPC1GAAMAPT | |
| SCHEMBL18106910 | 0.81 | MAOB (0.45) | SMN1; SMN2RAB9ANPC1MAOBADORA2A | |
| SCHEMBL6118547 | 0.80 | MAOB (0.65) | SMN1; SMN2RAB9ANPC1IRAK4MAOB | |
| SCHEMBL18106903 | 0.79 | IRAK4 (0.62) | SMN1; SMN2RAB9ANPC1IRAK4MAPT | |
| SCHEMBL18106906 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1MAOBADORA2A | |
| SCHEMBL1013853 | 0.78 | LMNA (0.54) | SMN1; SMN2RAB9ANPC1IRAK4PKN1 | |
| SCHEMBL11020624 | 0.75 | PKN1 (0.49) | SMN1; SMN2RAB9ANPC1IRAK4PKN1 | |
| Nitric Acid SCHEMBL11577224 | 0.73 | MGAM (0.48) | SMN1; SMN2RAB9ANPC1IRAK4MAOB | |
| SCHEMBL7478521 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1IRAK4PKN1 | |
| SCHEMBL8601355 | 0.73 | PKN1 (0.55) | SMN1; SMN2RAB9ANPC1IRAK4PKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742029-B1 | N-(BENZIMIMDAZOL-2-YL)-CYCLOPROPANE CARBOXAMIDES AS LYSOPHOSPHATIDIC ACID ANTAGONISTS | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |