Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30927142 | 1.00 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25197523 | 1.00 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3809154 | 0.95 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29918665 | 0.93 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1797263 | 0.89 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22749632 | 0.89 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29631723 | 0.83 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8781861 | 0.82 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29014615 | 0.80 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5722120 | 0.80 | MAOB (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240148732-A1 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISORDERS | SCHRÖDINGER, INC. | 2024-05-09 | — | — | US | disclosed |
| WO-2024064731-A2 | RAPID ENTRY INTO COTYLENIN CHEMICAL SPACE FOR DEVELOPMENT OF SELECTIVE 14-3-3 MOLECULAR GLUES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-03-28 | — | — | WO | disclosed |
| EP-4284804-A1 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISORDERS | Schrödinger, Inc. (US) | 2023-12-06 | — | — | EP | disclosed |
| CN-117120442-A | Tricyclic compounds useful for treating cancer, autoimmune disorders, and inflammatory disorders | 薛定谔公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022164789-A9 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISORDERS | SCHRÖDINGER, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2022164789-A1 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISODERS | SCHRÖDINGER, INC. (US) | 2022-08-04 | — | — | WO | disclosed |
| CN-107980011-B | Method for the homogeneous catalytic reduction of aminated carbonyl compounds | 巴斯夫欧洲公司 | 2020-10-27 | — | — | CN | disclosed |
| US-10450261-B2 | Method for the homogeneous catalytic reductive amination of carbonyl compounds | BASF SE (DE) | 2019-10-22 | — | — | US | disclosed |
| EP-3302795-B1 | METHOD FOR THE HOMOGENEOUS CATALYTIC REDUCTIVE AMINATION OF CARBONYL COMPOUNDS | BASF SE (DE) | 2019-07-31 | — | — | EP | disclosed |
| EP-2496556-B1 | ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2018-12-26 | — | — | EP | disclosed |
| US-20130123618-A1 | Imaging Agents | EMORY UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20120264790-A1 | ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-10-18 | — | — | US | disclosed |
| EP-2496556-A1 | ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011053948-A1 | ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2011-05-05 | — | — | WO | disclosed |
| US-20110033382-A1 | Imaging Agents | EMORY UNIVERSITY (US) | 2011-02-10 | — | — | US | disclosed |
| US-7294738-B2 | Phosphorous containing steroid mimics | RAJAGOPALAN RAGHAVAN | 2007-11-13 | — | — | US | disclosed |
| US-7294738-B2 | Phosphorous containing steroid mimics | RAJAGOPALAN RAGHAVAN | 2007-11-13 | — | — | US | disclosed |
| WO-2006055879-A2 | NOVEL PHOSPHOROUS CONTAINING STEROID MIMICS | BIOFLEXIS, LLC (US) | 2006-05-26 | — | — | WO | disclosed |
| US-20050137170-A1 | Novel phosphorous containing steroid mimics | BIOFLEXIS, LLC (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2002055470-A1 | METHOD FOR THE ENANTIOSELECTIVE PREPARATION OF ADDUCTS OF $G(A)-SUBSTITUTED PHENYLETHYLAMINE-CYCLOALKANES AND OF 2-ACETOXYACRYLONITRILE, INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF THE LATERAL CHAIN OF HARRINGTONINES | ONCOPHARM (FR) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033382-A1 | Imaging Agents | FOLH1, FABP7, SLC1A2 | PSEN1 1264/4885PSEN2 775/4885APH1B 2224/4885 |
| US-20240148732-A1 | TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISORDERS | MALT1, LITAF, IL2 | PSEN1 3417/4885PSEN2 3796/4885APH1B 2653/4885 |
| US-20120264790-A1 | ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | LPAR2, LIPG, EDF1 | PSEN1 4232/4885PSEN2 3249/4885APH1B 1449/4885 |
| US-20130123618-A1 | Imaging Agents | FOLH1, FABP7, SLC1A2 | PSEN1 1264/4885PSEN2 775/4885APH1B 2224/4885 |
| US-10450261-B2 | Method for the homogeneous catalytic reductive amination of carbonyl compounds | CAT, AOC1, CYCS | PSEN1 4396/4885PSEN2 3855/4885APH1B 2735/4885 |
| US-20050137170-A1 | Novel phosphorous containing steroid mimics | NR5A1, NR3C2, AR | PSEN1 1427/4885PSEN2 1907/4885APH1B 4495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.