Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 16/20 | 0.76 |
| ▸ | TPH2 | Q8IWU9 | 10/20 | 0.76 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812947 | 1.00 | TPH1 (0.76) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL613471 | 0.92 | TPH1 (0.63) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL12534386 | 0.91 | TPH1 (0.63) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL612056 | 0.91 | TPH1 (0.62) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL612058 | 0.91 | TPH1 (0.62) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL12534330 | 0.91 | TPH1 (0.62) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL612057 | 0.91 | TPH1 (0.62) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL870548 | 0.91 | TPH1 (0.79) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL871293 | 0.91 | TPH1 (0.79) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL609672 | 0.88 | TPH1 (0.58) | TPH1TPH2F2ESR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450532-B2 | Compounds useful in the preparation of tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TERSERA THERAPEUTICS LLC | 2011-06-02 | — | — | US | disclosed |
| WO-2011063072-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-26 | — | — | WO | disclosed |
| US-20110124865-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | LEXICON PHARMACEUTICALS, INC. | 2011-05-26 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897763-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7855291-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855291-B2 | Process for the preparation of substituted phenylalanines | LEXICON PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| WO-2010047712-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | TERSERA THERAPEUTICS LLC | 2009-05-07 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2009048864-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | TERSERA THERAPEUTICS LLC | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130564-A1 | COMPOUNDS USEFUL IN THE PREPARATION OF TRYPTOPHAN HYDRROXYLASE INHIBITORS | TPH1, TPH2, PAH | TPH1 1/4885TPH2 2/4885F2 707/4885 |
| US-20090099206-A1 | SOLID FORMS OF (S)-2-AMINO-3-(4-(2-AMINO-6-((R)-2,2,2-TRIFLUORO-1-(3'-METHOXYBIPHENYL-4-YL)ETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOIC ACID AND METHODS OF THEIR USE | PCCA, ANXA6, CPS1 | TPH1 2318/4885TPH2 1196/4885F2 483/4885 |
| US-20090118505-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | PAH, TYR, NPEPPS | TPH1 28/4885TPH2 64/4885F2 490/4885 |
| US-20110124865-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES | PAH, NPEPPS, DNPEP | TPH1 73/4885TPH2 106/4885F2 600/4885 |
| US-20090048280-A1 | Process for the preparation of substituted phenylalanines | PAH, TYR, NPEPPS | TPH1 28/4885TPH2 64/4885F2 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.