Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16406877 | 0.79 | ADRA2C (0.48) | MAOAMAOBNISCHADRA2CADRA2B | |
| SCHEMBL11259524 | 0.77 | MAOA (0.60) | MAOAMAOBNISCHADRA2CADRA2B | |
| Hydrochloric Acid SCHEMBL11254132 | 0.75 | MAOA (0.59) | MAOAMAOBNISCHADRA2CADRA2B | |
| SCHEMBL16406875 | 0.75 | TAAR1 (0.57) | ADRA2CADRA2BADRA2AADRA1AADRA1B | |
| SCHEMBL16406872 | 0.75 | ALDH1A1 (0.48) | ADRA2CADRA2BADRA2AALDH1A1MAPT | |
| SCHEMBL6772171 | 0.75 | ADRA2A (0.94) | ADRA2CADRA2BADRA2AADRA1AADRA1B | |
| SCHEMBL15378775 | 0.74 | MAOA (0.57) | MAOAMAOBNISCHADRA2CADRA2B | |
| SCHEMBL18330525 | 0.74 | MAOA (0.71) | MAOAMAOBNISCHADRA2CADRA2B | |
| SCHEMBL3173010 | 0.74 | MAOA (0.71) | MAOAMAOBNISCHADRA2CADRA2B | |
| SCHEMBL16406873 | 0.74 | MAOA (0.55) | MAOAMAOBNISCHADRA2CADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738628-B2 | Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160297801-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297801-A1 | SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, CTNNA1 | MAOA 4613/4885MAOB 4758/4885NISCH 4476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.