Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.37 |
| ▸ | ADH1C | P00326 | 1/20 | 0.37 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | ADH7 | P40394 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869526 | 0.78 | CTSL (0.32) | — | |
| SCHEMBL31214187 | 0.77 | ERN1 (0.34) | ADH1BADH1CADH1AADH7 | |
| SCHEMBL839538 | 0.72 | — | — | |
| SCHEMBL18397344 | 0.72 | — | — | |
| SCHEMBL22326459 | 0.71 | KDM1A (0.46) | ADH1BADH1CADH1AADH7 | |
| SCHEMBL13082139 | 0.71 | CCR4 (0.30) | — | |
| SCHEMBL18132263 | 0.71 | LOXL2 (0.32) | — | |
| SCHEMBL1864095 | 0.71 | KDM4E (0.32) | — | |
| SCHEMBL22345799 | 0.70 | TRPV3 (0.49) | — | |
| SCHEMBL22345802 | 0.70 | TRPV3 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531693-B | 5 or 8-substituted imidazo [1, 5-a ] pyridines as indoleamine, tryptophan dioxygenase inhibitors | 百济神州有限公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | BEIGENE, LTD. (KY) | 2020-05-12 | — | — | US | disclosed |
| CN-110872289-A | Novel 8-substituted imidazo [1,5-a ] pyridines as IDO1 and/or TDO inhibitors | 百济神州(北京)生物科技有限公司 | 2020-03-10 | — | — | CN | disclosed |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2019-09-19 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | IDO1, TPH1, IDO2 | ADH1B 257/4885ADH1C 531/4885ADH1A 168/4885 |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | IDO1, TPH1, IDO2 | ADH1B 257/4885ADH1C 531/4885ADH1A 168/4885 |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | IDO1, TPH1, IDO2 | ADH1B 246/4885ADH1C 521/4885ADH1A 135/4885 |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | IDO1, TPH1, IDO2 | ADH1B 257/4885ADH1C 519/4885ADH1A 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.