Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138241 | 0.85 | NOTUM (0.35) | PDE10ACRHR1NPC1 | |
| SCHEMBL12764246 | 0.82 | NPC1 (0.48) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL18138310 | 0.80 | KDM4E (0.40) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL18131175 | 0.77 | ALDH1A1 (0.48) | LMNAALDH1A1KMT2AMEN1POLB | |
| SCHEMBL29301330 | 0.75 | KDM4E (0.32) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL18138239 | 0.74 | DRD2 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL18138240 | 0.73 | FGFR1 (0.31) | PDE10AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL25330627 | 0.73 | MAP3K5 (0.38) | LMNAPDE10AKDM4EALDH1A1KMT2A | |
| SCHEMBL25334059 | 0.72 | EPHX2 (0.44) | LMNAPDE10AKDM4EALDH1A1KMT2A | |
| SCHEMBL18558956 | 0.71 | PDE10A (0.43) | LMNAPDE10AKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |