Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942172 | 0.91 | MKNK1 (0.50) | MKNK1MKNK2HTTFGFR1DRD2 | |
| Fumaric Acid SCHEMBL1811369 | 0.85 | HRH3 (0.52) | HTT | |
| Hydrochloric Acid SCHEMBL2887059 | 0.77 | CYP11B1 (0.56) | MKNK1MKNK2HTT | |
| SCHEMBL1816405 | 0.75 | HRH3 (0.53) | HTTFGFR1DRD2 | |
| Hydrochloric Acid SCHEMBL1816217 | 0.74 | HRH3 (0.52) | HTTFGFR1DRD2 | |
| SCHEMBL1814415 | 0.74 | HRH3 (0.52) | HTTFGFR1DRD2 | |
| SCHEMBL1814978 | 0.74 | MCHR1 (0.43) | — | |
| SCHEMBL14223274 | 0.73 | HTT (0.57) | HTTFGFR1HTR2AHTR2B | |
| SCHEMBL1808788 | 0.71 | DRD2 (0.41) | HTTFGFR1DRD2 | |
| SCHEMBL24093258 | 0.71 | HTT (0.45) | HTTFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935719-B2 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH LLC (US) | 2011-05-03 | — | — | US | disclosed |