Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805993 | 0.89 | MAOA (0.56) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL21052518 | 0.85 | PBRM1 (0.53) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL1468060 | 0.82 | CASP1 (0.55) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL31597656 | 0.82 | SRD5A1 (0.40) | CASP1CASP7HSD17B10SRD5A1MAOB | |
| SCHEMBL18829264 | 0.81 | MAOA (0.47) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL18290555 | 0.81 | CASP1 (0.53) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL12745029 | 0.78 | CASP1 (0.50) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL19828934 | 0.77 | ALDH1A1 (0.37) | SRD5A1CYP26A1MIF | |
| SCHEMBL1466993 | 0.77 | CASP1 (0.49) | CASP1CASP7HSD17B10HSD17B1SRD5A1 | |
| SCHEMBL1466994 | 0.77 | CASP1 (0.49) | CASP1CASP7HSD17B10HSD17B1SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720597-B1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES | STICHTING TECHNISCHE WETENSCHAPPEN (NL) | 2023-11-29 | — | — | EP | claimed |
| US-11612877-B2 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-03-28 | — | — | US | claimed |
| US-20200368721-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2020-11-26 | — | — | US | claimed |
| EP-3720597-A1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF | Stichting voor de Technische Wetenschappen (NL) | 2020-10-14 | — | — | EP | claimed |
| WO-2019110557-A1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2019-06-13 | — | — | WO | claimed |
| US-12318756-B2 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | UNIVERSITEIT UTRECHT HOLDING B.V. (NL) | 2025-06-03 | — | — | US | disclosed |
| EP-3720597-B1 | MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES | STICHTING TECHNISCHE WETENSCHAPPEN (NL) | 2023-11-29 | — | — | EP | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-11612877-B2 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-03-28 | — | — | US | disclosed |
| US-20200368721-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2020-11-26 | — | — | US | disclosed |
| WO-2012177813-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012177813-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2012-12-27 | — | — | WO | disclosed |
| CN-102686571-A | Tricyclic heterocyclic compounds | BRISTOL MYERS SQUIBB CO | 2012-09-19 | — | — | CN | disclosed |
| EP-2493866-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2012-08-23 | — | — | US | disclosed |
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2012-08-23 | — | — | US | disclosed |
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2012-08-23 | — | — | US | disclosed |
| WO-2011059784-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214767-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | S1PR1, S1PR3, TBXA2R | CASP1 1065/4885CASP7 3044/4885HSD17B10 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.