Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466018 | 0.89 | MAOA (0.58) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL6659325 | 0.87 | SRD5A1 (0.46) | CASP1CASP7HSD17B10MEN1ALDH1A1 | |
| SCHEMBL7231960 | 0.84 | PBRM1 (0.55) | CASP1CASP7HSD17B10HSD17B1MAOB | |
| SCHEMBL18290555 | 0.82 | CASP1 (0.53) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL1815040 | 0.82 | CASP1 (0.53) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL13691966 | 0.80 | ALDH1A1 (0.41) | CASP1CASP7HSD17B10MEN1ALDH1A1 | |
| SCHEMBL12745029 | 0.79 | CASP1 (0.50) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL11818515 | 0.78 | SRD5A1 (0.51) | MAOBMEN1ALDH1A1GAAMAPT | |
| SCHEMBL1466994 | 0.78 | CASP1 (0.49) | CASP1CASP7HSD17B10HSD17B1GRM5 | |
| SCHEMBL1466993 | 0.78 | CASP1 (0.49) | CASP1CASP7HSD17B10HSD17B1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-3153497-A2 | PESTICIDAL CARBOXAMIDES | Bayer Cropscience AG (DE) | 2017-04-12 | — | — | EP | disclosed |
| US-8153671-B2 | Heterotetracyclic compounds as TPO mimetics | IRM LLC (BM) | 2012-04-10 | — | — | US | disclosed |
| US-20110071141-A1 | Pesticidial Condensed-Ring Aryl Compounds | BAYER CROPSCIENCE AG | 2011-03-24 | — | — | US | disclosed |
| US-20110071141-A1 | Pesticidial Condensed-Ring Aryl Compounds | BAYER CROPSCIENCE AG | 2011-03-24 | — | — | US | disclosed |
| US-20110071141-A1 | Pesticidial Condensed-Ring Aryl Compounds | BAYER CROPSCIENCE AG | 2011-03-24 | — | — | US | disclosed |
| CN-101970403-A | Insecticidal fused ring aryl compounds | BAYER CROPSCIENCE AG | 2011-02-09 | — | — | CN | disclosed |
| EP-2254863-A1 | PESTICIDAL CONDENSED - RING ARYL COMPOUNDS | Bayer CropScience AG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009112275-A1 | PESTICIDAL CONDENSED - RING ARYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009112275-A1 | PESTICIDAL CONDENSED - RING ARYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| US-20090075996-A1 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM LLC (BM) | 2009-03-19 | — | — | US | disclosed |
| US-7452906-B2 | Pyridine derivatives as Raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2008-11-18 | — | — | US | disclosed |
| US-7297694-B2 | Pyridylfurans and pyrroles as Raf kinase inhibitors | SMITHKLINE BEECHUM P.L.C. (GB) | 2007-11-20 | — | — | US | disclosed |
| EP-1423384-B1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2007-05-23 | — | — | EP | disclosed |
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-12-16 | — | — | US | disclosed |
| US-20040235843-A1 | Pyridine derivatives as raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-11-25 | — | — | US | disclosed |
| EP-1432697-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-30 | — | — | EP | disclosed |
| EP-1423384-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003022833-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2003-03-20 | — | — | WO | disclosed |
| WO-2003022840-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071141-A1 | Pesticidial Condensed-Ring Aryl Compounds | DDT, PRDX4, CYP4X1 | CASP1 580/4885CASP7 217/4885HSD17B10 2993/4885 |
| US-20040235843-A1 | Pyridine derivatives as raf kinase inhibitors | BRAF, RAF1, ARAF | CASP1 1487/4885CASP7 2633/4885HSD17B10 3788/4885 |
| US-20090075996-A1 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | MPL, TPO, THPO | CASP1 1785/4885CASP7 2344/4885HSD17B10 3821/4885 |
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | BRAF, ARAF, RAF1 | CASP1 1397/4885CASP7 2989/4885HSD17B10 4040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.