Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.30 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15315512 | 0.97 | CD274 (0.33) | CD274CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30175150 | 0.95 | MAPT (0.34) | CD274MAPTGRM3SLC6A12 | |
| SCHEMBL13988230 | 0.95 | MAPT (0.34) | CD274MAPTGRM3SLC6A12 | |
| SCHEMBL13988154 | 0.94 | MAPT (0.33) | CD274MAPTGRM3SLC6A12 | |
| SCHEMBL1818315 | 0.92 | KCNH2 (0.33) | MAPT | |
| SCHEMBL13988137 | 0.91 | HRH3 (0.31) | CD274MAPT | |
| SCHEMBL1046925 | 0.89 | KCNH2 (0.33) | — | |
| SCHEMBL29453300 | 0.89 | KCNH2 (0.33) | — | |
| SCHEMBL13988158 | 0.87 | PRKDC (0.33) | — | |
| SCHEMBL13988135 | 0.86 | SLC6A12 (0.31) | SLC6A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494408-B9 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2494408-B1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8518305-B2 | Photochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110108781-A1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110108781-A1 | PHOTOCHROMIC MATERIALS | INCENP, SMCHD1, NEDD8 | CD274 4575/4885CHRNB2 2187/4885CHRNB4 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.