Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152573 | 0.71 | ADAM17 (0.54) | ALOX5L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL18162676 | 0.71 | FASN (0.41) | ALOX5FASNKDM4ETP53NOX4 | |
| SCHEMBL2671424 | 0.70 | ALOX5 (0.51) | ALOX5KMT2AKDM4ETP53 | |
| SCHEMBL28446100 | 0.69 | CHUK (0.56) | L3MBTL1MEN1KMT2AFASNKDM4E | |
| SCHEMBL2673327 | 0.69 | ALOX5 (1.00) | ALOX5KDM4ETP53 | |
| SCHEMBL22533700 | 0.68 | GSK3A (0.53) | ALOX5L3MBTL1CSF1RMEN1KMT2A | |
| SCHEMBL25071639 | 0.68 | L3MBTL1 (0.48) | L3MBTL1CSF1RMEN1KMT2AFASN | |
| SCHEMBL30545930 | 0.68 | CHUK (0.68) | L3MBTL1MEN1KMT2AFASNCHUK | |
| SCHEMBL29402283 | 0.68 | CHUK (0.68) | L3MBTL1MEN1KMT2AFASNCHUK | |
| SCHEMBL606784 | 0.68 | CHUK (0.68) | L3MBTL1MEN1KMT2AFASNCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294726-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-21 | — | — | EP | claimed |
| WO-2016168633-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | claimed |