Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17559115 | 0.81 | KDM4E (0.56) | ALOX5ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL17559152 | 0.81 | KDM4E (0.56) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL28342517 | 0.78 | GABRA1 (0.62) | ADAM17MMP1MMP2MMP3MMP9 | |
| SCHEMBL9923022 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL8213257 | 0.77 | ALOX5 (0.58) | ALOX5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6406367 | 0.72 | GAA (0.74) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL18152286 | 0.71 | ALOX5 (0.51) | ALOX5KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL2671424 | 0.71 | ALOX5 (0.51) | ALOX5ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL26767757 | 0.71 | MAPT (0.51) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL12285521 | 0.71 | ABCG2 (0.83) | ALDH1A1KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294726-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-21 | — | — | EP | claimed |
| WO-2016168633-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | claimed |