Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18153773 | 0.91 | MEN1 (0.39) | OPRM1OPRD1MEN1KMT2AADRA2A | |
| SCHEMBL18152170 | 0.87 | MEN1 (0.39) | OPRM1OPRD1MEN1KMT2AADRA2A | |
| SCHEMBL18152144 | 0.82 | OPRM1 (0.38) | OPRM1OPRD1ADRA2A | |
| SCHEMBL18152111 | 0.79 | HSD17B2 (0.40) | ALOX5OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL18152130 | 0.78 | ALOX5 (0.38) | ALOX5LPAR1LPAR5OPRM1OPRD1 | |
| SCHEMBL18144826 | 0.75 | CHRNB2 (0.39) | MEN1KMT2A | |
| SCHEMBL18152186 | 0.74 | CYP2D6 (0.38) | OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL18165456 | 0.73 | MAPT (0.43) | MEN1KMT2A | |
| SCHEMBL18153894 | 0.72 | MEN1 (0.38) | OPRM1OPRD1MEN1KMT2AADRA2A | |
| SCHEMBL18153708 | 0.72 | MEN1 (0.38) | OPRM1OPRD1MEN1KMT2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | claimed |
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |