SCHEMBL1815487

SCHEMBL1815487

CC(=O)c1cc(C(=O)O)[nH]n1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.48
HCAR2 Q8TDS4 5/20 0.48
DAO P14920 1/20 0.48
ALPL P05186 9/20 0.47
TP53 P04637 1/20 0.47
HCAR3 P49019 3/20 0.46
CA9 Q16790 4/20 0.45
CA12 O43570 4/20 0.44
RPA1 P27694 1/20 0.43
ALOX15 P16050 1/20 0.42
PIN1 Q13526 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12011328 0.87 MAPK1 (0.52) MAPK1HCAR2DAOALPLHCAR3
SCHEMBL70577 0.85 HCAR2 (0.59) MAPK1HCAR2DAOALPLTP53
SCHEMBL12168148 0.83 HCAR2 (0.59) MAPK1HCAR2DAOHCAR3
Water SCHEMBL1267709 0.83 HCAR2 (0.57) MAPK1HCAR2DAOALPLTP53
SCHEMBL19987833 0.83 HCAR2 (0.57) MAPK1HCAR2DAOALPLTP53
Hydrochloric Acid SCHEMBL7723258 0.83 HCAR2 (0.57) MAPK1HCAR2DAOALPLTP53
Hydrochloric Acid SCHEMBL11595364 0.83 HCAR2 (0.57) MAPK1HCAR2DAOALPLTP53
SCHEMBL28638090 0.83 HCAR2 (0.57) MAPK1HCAR2DAOALPLTP53
Ammonia Solution, Strong SCHEMBL28463590 0.81 HCAR2 (0.55) MAPK1HCAR2DAOALPLTP53
SCHEMBL8068032 0.79 TP53 (0.47) MAPK1HCAR2DAOALPLTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025037054-A1 PROCESS FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF ORION CORPORATION (FI) 2025-02-20 WO disclosed
EP-3885340-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2024-11-27 EP disclosed
US-20240208985-A2 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-06-27 US disclosed
US-20240208985-A2 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-06-27 US disclosed
US-11919888-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2024-03-05 US disclosed
US-11851443-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-12-26 US disclosed
US-20230312537-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-10-05 US disclosed
US-20230312537-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-10-05 US disclosed
US-20230312537-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-10-05 US disclosed
US-20230174517-A1 METHOD FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF ORION CORPORATION (FI) 2023-06-08 US disclosed
WO-2013132376-A1 MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES PFIZER INC. (US) 2013-09-12 WO disclosed
CN-103261164-A Enkephalinase inhibitors THERAVANCE INC 2013-08-21 CN disclosed
CN-103068813-A Anthranilic acid diamide derivatives BAYER CROPSCIENCE AG 2013-04-24 CN disclosed
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-09-06 US disclosed
EP-2493858-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS Orion Corporation (FI) 2012-09-05 EP disclosed
CN-102596910-A Androgen receptor modulating compounds ORION CORP 2012-07-18 CN disclosed
US-20120157383-A1 NEPRILYSIN INHIBITORS THERAVANCE, INC. (US) 2012-06-21 US disclosed
WO-2011051540-A9 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-06-21 WO disclosed
WO-2012082853-A1 NEPRILYSIN INHIBITORS THERAVANCE, INC. (US) 2012-06-21 WO disclosed
WO-2011051540-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2011-05-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174517-A1 METHOD FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF AR, GNRHR, FSHR MAPK1 2746/4885HCAR2 187/4885DAO 1433/4885
US-20240208985-A2 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS AR, SHBG, NR5A1 MAPK1 1477/4885HCAR2 254/4885DAO 3457/4885
US-20230312537-A1 NEPRILYSIN INHIBITORS MME, REN, ACE MAPK1 1342/4885HCAR2 658/4885DAO 1503/4885
US-20120157383-A1 NEPRILYSIN INHIBITORS MME, REN, ACE MAPK1 1373/4885HCAR2 1705/4885DAO 1777/4885
US-20120225867-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS AR, NR5A1, SHBG MAPK1 1682/4885HCAR2 364/4885DAO 4531/4885
US-11851443-B2 Neprilysin inhibitors MME, REN, ACE MAPK1 1373/4885HCAR2 1705/4885DAO 1777/4885
US-11919888-B2 Neprilysin inhibitors MME, REN, ACE MAPK1 1342/4885HCAR2 658/4885DAO 1503/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.