Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522126 | 0.83 | ALDH1A1 (0.51) | GAAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2523126 | 0.80 | GAA (0.44) | GAAMEN1KMT2AKDM4EPOLB | |
| SCHEMBL2517806 | 0.77 | GAA (0.46) | GAAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8385965 | 0.68 | MEN1 (0.44) | GAAMEN1KMT2AKDM4EPOLB | |
| SCHEMBL28969335 | 0.65 | MEN1 (0.46) | GAAMEN1KMT2AKDM4EPOLB | |
| SCHEMBL6970538 | 0.65 | MEN1 (0.49) | GAAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5106132 | 0.64 | KDM4E (0.43) | GAAMEN1KMT2AKDM4EPOLB | |
| SCHEMBL14444936 | 0.64 | TXNRD1 (0.47) | MAPTNPSR1 | |
| SCHEMBL23066567 | 0.63 | PKM (0.43) | GAAMEN1KMT2AKDM4EPOLB | |
| SCHEMBL18366033 | 0.63 | POLB (0.43) | GAAMEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556066-B1 | PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |