Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18156765 | 0.87 | ESR1 (0.37) | RECQLALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL20224492 | 0.85 | RECQL (0.36) | RECQLALDH1A1SMN1; SMN2MEN1MAPT | |
| SCHEMBL18314568 | 0.84 | PSMD14 (0.34) | PSMD14POLBRECQLL3MBTL1ALDH1A1 | |
| SCHEMBL23894908 | 0.81 | PPARG (0.33) | PDE10A | |
| SCHEMBL24674258 | 0.80 | KDM4E (0.36) | POLBALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL24673735 | 0.80 | KDM4E (0.36) | POLBALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL19315574 | 0.80 | ALDH1A1 (0.36) | POLBL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19315737 | 0.80 | MEN1 (0.33) | POLBALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18156764 | 0.80 | ESR1 (0.39) | RECQLALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL20224493 | 0.80 | SIRT2 (0.33) | MEN1MAPTKMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | PSMD14 4642/4885POLB 3232/4885RECQL 1091/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | PSMD14 4642/4885POLB 3232/4885RECQL 1091/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | PSMD14 4642/4885POLB 3232/4885RECQL 1091/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | PSMD14 4642/4885POLB 3232/4885RECQL 1091/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | PSMD14 4642/4885POLB 3232/4885RECQL 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.