Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30934 | 0.82 | TRPA1 (0.77) | TRPA1CYP2D6SIGMAR1TAAR1SLC6A2 | |
| Methamphetamine SCHEMBL28255325 | 0.82 | SIGMAR1 (0.72) | SIGMAR1TAAR1SLC6A4SLC18A2MEN1 | |
| Methamphetamine SCHEMBL326876 | 0.80 | SIGMAR1 (0.70) | SIGMAR1TAAR1SLC6A4SLC18A2MEN1 | |
| SCHEMBL1140503 | 0.80 | TRPA1 (0.74) | TRPA1CYP2D6SIGMAR1TAAR1SLC6A2 | |
| Water SCHEMBL3896311 | 0.80 | TRPA1 (0.74) | TRPA1CYP2D6SIGMAR1TAAR1SLC6A2 | |
| Methamphetamine SCHEMBL10280466 | 0.79 | SIGMAR1 (0.68) | SIGMAR1TAAR1SLC6A4SLC18A2MEN1 | |
| SCHEMBL9735526 | 0.78 | TRPA1 (0.71) | TRPA1CYP2D6SIGMAR1TAAR1SLC6A2 | |
| Ethylbenzene SCHEMBL3255269 | 0.77 | TP53 (0.64) | SIGMAR1MEN1KMT2A | |
| Naphthalene SCHEMBL17141391 | 0.76 | TRPA1 (0.68) | TRPA1CYP2D6SIGMAR1TAAR1SLC6A2 | |
| Tetrahydrofuran SCHEMBL8893050 | 0.76 | SIGMAR1 (0.52) | SIGMAR1TAAR1SLC6A3MAOACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113845554-A | Method for extracting benzofuran lignan diastereoisomer from medicinal mulberry | 塔里木大学 | 2021-12-28 | — | — | CN | claimed |
| CN-107522706-B | Parallel double tetrahydrofuran lignans and its preparation method and application | 海南师范大学 | 2019-08-13 | — | — | CN | claimed |
| CN-109369665-A | The method of double tetrahydrofuran lignans is extracted from the tea of South Mountain | 中南林业科技大学 | 2019-02-22 | — | — | CN | claimed |
| CN-107522706-A | Parallel double tetrahydrofuran lignans and its preparation method and application | 海南师范大学 | 2017-12-29 | — | — | CN | claimed |
| CN-101305728-B | Use of double tetrahydrofuran lignans compound with fungicidal property | RES AND SERVICE CT OF BIORATIONAL PESTICIDE NORTHWEST AGRICULTURE AND FORESTRY UNIVERSITY | 2011-06-08 | — | — | CN | claimed |
| CN-101305728-A | Application of bi-tetrahydrofuran lignan compound with bactericidal activity | BIORATIONAL PESTICIDE RES AND (CN) | 2008-11-19 | — | — | CN | claimed |
| CN-113845554-B | Method for extracting polytetrahydrofuran lignan diastereoisomer from medicinal mulberry | 塔里木大学 | 2024-01-16 | — | — | CN | disclosed |
| CN-114308125-A | Preparation method and application of eosin Y-based metal organic framework with function of activating inert C-H bond | 大连理工大学 | 2022-04-12 | — | — | CN | disclosed |
| CN-113845554-A | Method for extracting benzofuran lignan diastereoisomer from medicinal mulberry | 塔里木大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-113845554-A | Method for extracting benzofuran lignan diastereoisomer from medicinal mulberry | 塔里木大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-110511194-B | Tetrahydrofuran type lignan compound and preparation method and application thereof | 沈阳药科大学 | 2021-03-05 | — | — | CN | disclosed |
| CN-107522706-B | Parallel double tetrahydrofuran lignans and its preparation method and application | 海南师范大学 | 2019-08-13 | — | — | CN | disclosed |
| CN-107522706-B | Parallel double tetrahydrofuran lignans and its preparation method and application | 海南师范大学 | 2019-08-13 | — | — | CN | disclosed |
| US-4977146-A | ANTICOAGULANT | MERCK & CO., INC. (US) | 1990-12-11 | — | — | US | disclosed |
| EP-0144804-B1 | NEW 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF-ANTAGONISTS | MERCK & CO. INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0199324-A2 | New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4595693-A | Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists | MERCK & CO., INC. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4539332-A | PLATELET ACTIVATION FACTOR | MERCK & CO., INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0144804-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf-antagonists | MERCK & CO. INC. (US) | 1985-06-19 | — | — | EP | disclosed |