Tetrahydrofuran

Tetrahydrofuran

SCHEMBL8893050

C1CCOC1.c1ccc(CCc2ccccc2)cc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.52
POLB P06746 1/20 0.52
FKBP1A P62942 1/20 0.52
LMNA P02545 1/20 0.47
FFAR1 O14842 1/20 0.46
MAOA P21397 2/20 0.46
MAOB P27338 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
ALOX12 P18054 1/20 0.46
CASP1 P29466 1/20 0.46
HSD17B10 Q99714 1/20 0.46
SLC6A3 Q01959 1/20 0.45
TSHR P16473 1/20 0.45
KEAP1 Q14145 1/20 0.44
TDP1 Q9NUW8 3/20 0.44
CYP2A6 P11509 1/20 0.44
HTR2A P28223 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL27959573 0.83 FKBP1A (0.44) SIGMAR1POLBFKBP1ALMNAALDH1A1
Phenyl Propionic Acid SCHEMBL29256162 0.82 KEAP1 (0.70) FKBP1ALMNAFFAR1ALDH1A1SLC6A3
Ethylbenzene SCHEMBL3255269 0.81 TP53 (0.64) SIGMAR1POLBFKBP1ALMNAALDH1A1
(Chloromethyl)Benzene SCHEMBL27762297 0.81 FKBP1A (0.41) SIGMAR1POLBFKBP1ALMNAALDH1A1
Benzyl Bromide SCHEMBL17239892 0.81 ALDH1A1 (0.64) SIGMAR1POLBFKBP1ALMNAALDH1A1
Benzylamine SCHEMBL27576789 0.81 LOXL2 (0.64) SIGMAR1POLBFKBP1ALMNAMAOB
Benzyl Alcohol SCHEMBL969382 0.81 TSHR (0.64) SIGMAR1POLBFKBP1ALMNAALDH1A1
Cyclooctane SCHEMBL18187569 0.81 SIGMAR1 (0.58) SIGMAR1MAOAMAOBALDH1A1HPGD
Fluoride SCHEMBL27972865 0.81 ALDH1A1 (0.65) SIGMAR1FFAR1MAOAMAOBALDH1A1
Tetrahydrofuran SCHEMBL28927730 0.80 FKBP1A (0.57) FKBP1AFFAR1ALDH1A1HPGDSLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5698524-A PREPARING WATER SOLUBLE REACTION PRODUCT POLYMER OF LIGNIN AND LIGNOID THAT HAVE EACH BEEN EXTRACTED FROM WOOD OR WOOD-LIKE MATERIALS UNDER ACIDIC AND/OR ALKALINE CONDITIONS MACH WALTER (DE) 1997-12-16 US disclosed
US-5554596-A POLYMER WITH LIGNIN UNITS AND LIGNOID UNITS MACH WALTER (DE) 1996-09-10 US disclosed