Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 18/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817248 | 0.87 | NOTUM (0.60) | NOTUMS1PR1PDK2 | |
| SCHEMBL3598011 | 0.76 | ABHD6 (0.46) | NOTUM | |
| SCHEMBL15547228 | 0.73 | WDR5 (0.44) | NOTUM | |
| SCHEMBL2968971 | 0.72 | NOTUM (0.65) | NOTUM | |
| SCHEMBL2431606 | 0.71 | HRH3 (0.52) | — | |
| SCHEMBL24177167 | 0.71 | CES2 (0.47) | — | |
| SCHEMBL29789661 | 0.71 | CES2 (0.47) | — | |
| SCHEMBL15923406 | 0.71 | IP6K1 (0.58) | NOTUM | |
| Trifluoroacetic Acid SCHEMBL3475248 | 0.71 | HRH3 (0.49) | — | |
| SCHEMBL2938165 | 0.69 | NOTUM (0.75) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951805-B2 | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase | XENON PHARMACEUTICALS INC. (CA) | 2011-05-31 | — | — | US | disclosed |