Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816201 | 0.87 | NOTUM (0.56) | NOTUMPDK2S1PR1 | |
| SCHEMBL4412651 | 0.82 | NOTUM (0.63) | NOTUMPDK2SERPINE1S1PR1 | |
| SCHEMBL25172425 | 0.80 | NOTUM (0.60) | NOTUMPDK2SERPINE1S1PR1 | |
| SCHEMBL3598011 | 0.79 | ABHD6 (0.46) | NOTUM | |
| SCHEMBL640945 | 0.79 | NOTUM (0.53) | NOTUMPDK2SERPINE1FFAR4 | |
| SCHEMBL25209622 | 0.79 | NOTUM (0.59) | NOTUMPDK2SERPINE1 | |
| SCHEMBL641081 | 0.76 | FFAR4 (0.55) | NOTUMPDK2FFAR4 | |
| SCHEMBL15923406 | 0.75 | IP6K1 (0.58) | NOTUMSERPINE1 | |
| SCHEMBL2071701 | 0.75 | NOTUM (0.83) | NOTUMPDK2SERPINE1FFAR4 | |
| SCHEMBL2431606 | 0.74 | HRH3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951805-B2 | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase | XENON PHARMACEUTICALS INC. (CA) | 2011-05-31 | — | — | US | disclosed |