Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166425 | 0.91 | KMT2A (0.44) | KMT2AROCK2CYP3A4ROCK1TSHR | |
| SCHEMBL18166321 | 0.90 | KMT2A (0.44) | KMT2AROCK2CYP3A4ROCK1TSHR | |
| SCHEMBL10243335 | 0.86 | P2RX3 (0.48) | ROCK2CYP3A4ROCK1TSHRP2RX3 | |
| SCHEMBL18166309 | 0.85 | KMT2A (0.46) | KMT2ATSHRP2RX3P2RX2CTSK | |
| SCHEMBL18166395 | 0.84 | KMT2A (0.41) | KMT2ATSHRP2RX3P2RX2TP53 | |
| SCHEMBL18166305 | 0.84 | P2RX3 (0.53) | P2RX3P2RX2 | |
| SCHEMBL18166377 | 0.83 | KMT2A (0.44) | KMT2ATSHRP2RX3P2RX2TP53 | |
| SCHEMBL18036403 | 0.82 | KMT2A (0.46) | KMT2ATSHRP2RX3P2RX2TP53 | |
| SCHEMBL18166427 | 0.82 | P2RX3 (0.55) | KMT2AROCK2CYP3A4ROCK1P2RX3 | |
| SCHEMBL18036460 | 0.81 | KMT2A (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |