Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166450 | 0.94 | P2RX3 (0.54) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166300 | 0.91 | P2RX3 (0.46) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166451 | 0.91 | P2RX3 (0.45) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166362 | 0.88 | P2RX3 (0.41) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL10243431 | 0.87 | P2RX3 (0.63) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166396 | 0.85 | P2RX3 (0.39) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166458 | 0.85 | P2RX3 (0.34) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166418 | 0.85 | P2RX3 (0.39) | P2RX3P2RX2POLBGAASMN1; SMN2 | |
| SCHEMBL18166441 | 0.84 | P2RX3 (0.68) | P2RX3P2RX2 | |
| SCHEMBL18036445 | 0.83 | P2RX3 (0.47) | P2RX3P2RX2GAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |