Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166295 | 0.92 | P2RX3 (0.35) | P2RX3P2RX2EPHX1MAP3K5ALOX5 | |
| SCHEMBL18166448 | 0.92 | P2RX3 (0.35) | P2RX3P2RX2ALDH1A1TSHREPHX1 | |
| SCHEMBL18166446 | 0.86 | P2RX3 (0.45) | P2RX3P2RX2 | |
| SCHEMBL10244122 | 0.86 | P2RX3 (0.45) | P2RX3P2RX2IRAK4TSHR | |
| SCHEMBL18166368 | 0.84 | P2RX3 (0.47) | P2RX3P2RX2EPHX1 | |
| SCHEMBL18166376 | 0.83 | P2RX3 (0.39) | P2RX3P2RX2EPHX1NPC1RAB9A | |
| SCHEMBL18166336 | 0.82 | P2RX3 (0.40) | P2RX3P2RX2 | |
| SCHEMBL18166430 | 0.82 | ADORA2A (0.41) | P2RX3P2RX2EPHX1MAP3K5 | |
| SCHEMBL18166317 | 0.82 | P2RX3 (0.37) | P2RX3P2RX2 | |
| SCHEMBL18166413 | 0.81 | P2RX3 (0.41) | P2RX3P2RX2ALDH1A1TSHREPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |