Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10244013 | 0.86 | P2RX3 (0.50) | P2RX3P2RX2 | |
| SCHEMBL18166368 | 0.85 | P2RX3 (0.47) | P2RX3P2RX2 | |
| SCHEMBL18166317 | 0.85 | P2RX3 (0.37) | P2RX3P2RX2HTTMAPTSMN1; SMN2 | |
| SCHEMBL18166362 | 0.84 | P2RX3 (0.41) | P2RX3P2RX2HTTMAPTSMN1; SMN2 | |
| SCHEMBL18166413 | 0.84 | P2RX3 (0.41) | P2RX3P2RX2HTTMAPTSMN1; SMN2 | |
| SCHEMBL18166446 | 0.84 | P2RX3 (0.45) | P2RX3P2RX2 | |
| SCHEMBL18166430 | 0.83 | ADORA2A (0.41) | P2RX3P2RX2SMN1; SMN2 | |
| SCHEMBL18166384 | 0.82 | P2RX3 (0.36) | P2RX3P2RX2 | |
| SCHEMBL18166320 | 0.82 | P2RX3 (0.37) | P2RX3P2RX2HTTMAPT | |
| SCHEMBL18166376 | 0.82 | P2RX3 (0.39) | P2RX3P2RX2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |